Universität Bonn

Institute for Physiology

en

Fleischmann Laboratory

Diseases of the cardiovascular system are the leading cause of death in the Western world. The Institute of Physiology I aims to improve the understanding of the physiology of the developing and diseased heart. Ongoing work includes elucidation of key cardiac functions, i.e., initiation and regulation of spontaneous activity. To this end, molecular, cell biological and physiological techniques are combined with transgenic mouse models and embryonic stem cell models. A major focus of the group is the improvement of cardiac function after irreversible loss of cardiac cells. This strategy is currently being tested by experimental transplantation of primary and stem cell-derived cardiac cells into the infarct-damaged mouse heart.

Prof. Dr. med Bernd K. Fleischmann

Head of the Institute of Physiology I at the Faculty of Medicine

Life & Brain Center

Venusberg-Campus 1

53127 Bonn

Research

Research areas

Diseases of the cardiovascular system are the leading cause of death in the Western world. The Institute of Physiology I aims to improve the understanding of the physiology of the developing and diseased heart. Ongoing work includes elucidation of key cardiac functions, i.e., initiation and regulation of spontaneous activity. To this end, molecular, cell biological and physiological techniques are combined with transgenic mouse models and embryonic stem cell models. A major focus of the group is the improvement of cardiac function after irreversible loss of cardiac cells. This strategy is currently being tested by experimental transplantation of primary and stem cell-derived cardiac cells into the infarct-damaged mouse heart.

Wir untersuchen diese Fragen auf drei Ebenen

Verhalten. Neuronale Schaltkreise. Gene.

Dazu nutzen wir Modellorganismen wie die genetische Modellfliege Drosophila melanogaster und die Maus in Kombination mit modernen Methoden der Verhaltensanalyse, der (Opto)-genetik und in vivo Mikroskopie.

Eine Wissenschaftlerin und ein Wissenschaftler arbeiten hinter einer Glasfassade und mischen Chemikalien mit Großgeräten.
© MPI of Neurobiology/ Friedrich

Einfluss von physiologischem Zustand auf Verhalten und neuronale Schaltkreise

Erfahren Sie, wie unser physiologischer Zustand und unsere Bedürfnisse Einfluss auf Verhalten und neuronale Schaltkreise ausüben.

Eine Wissenschaftlerin und ein Wissenschaftler arbeiten hinter einer Glasfassade und mischen Chemikalien mit Großgeräten.
© Sophie Aimon

Einfluss des Verhaltenszustandes auf Entscheidungsfindung und Wahrnehmung

Entdecken Sie den Einfluss unseres Verhaltenszustandes auf unsere Entscheidungsfindung und Wahrnehmung.

Eine Wissenschaftlerin und ein Wissenschaftler arbeiten hinter einer Glasfassade und mischen Chemikalien mit Großgeräten.
© Uni Bonn

Projektgruppe Dr. Annika Cichy –  Modulation der Sinne durch Hormone

Die Projektgruppe von Frau Dr. Annika Cichy erforscht die Modulation der Sinneswahrnehmung durch Hormone.

Riechen und schmecken, was gut ist

Dieses Forschungsprojekt untersucht, wie wichtige Nährstoffe, sogenannte Polyamine, durch den Geruchs- und Geschmackssinn erkannt werden.

Wie Schwangerschaft die Wahrnehmung verändert

Lesen Sie, wie sich in der Schwangerschaft die Wahrnehmung und Reaktionen auf bestimmte Gerüche und Geschmäcker verändert.

Hunger beeinflusst Entscheidungen 

Erfahren Sie, wie Hunger unsere Entscheidungen und unser Risikoempfinden beeinflusst. Ein gewisser Hunger macht risikofreudig.

Head of the Institute

Secretary

Regina Bek

+49 228 287 62200

+49 228 287 62201

  Administrative and Technical Support 

Patricia Freitag

+49 228 287 62226

Technical assistant

Sabine Grünberg

+49 228 287 62226

Technical assistant

Astrid Markert

+49 228 287 62226

Technical assistant

Research assistants / postdocs

Dr. rer. nat. Caroline Geisen

+49 228 287 62223

Priv. Doz. Dr. rer. nat. Michael Hesse

+49 228 287 62136

Dr. rer. nat. Sarah Rieck

+49 228 287 62233

  PhD students

Alumni

Aufklapp-Text

Publications

Publikationen

  • Aimon S, Cheng KY, Gjorgjieva J, Grunwald Kadow IC. Walking elicits global brain activity in Drosophila. BioRxiv. doi: [link]
     
  • Ariane C Boehm, Anja B Friedrich, Sydney Hunt, Paul Bandow, K.P. Siju, Jean-Francois De Backer, Julia Claussen, Marie-Helen Link, Thomas F Hofmann, Corinna Dawid, Ilona C Grunwald Kadow. A distributed dopamine-gated circuit underpins reproductive state-dependent behavior in Drosophila females. [link]
     
  • K.P. Siju, Vilim Stih, Sophie Aimon, Julijana Gjorgjieva, Ruben Portugues, Ilona C. Grunwald Kadow. Valence and state-dependent population coding in dopaminergic neurons in the fly mushroom body. doi: [link]
    • Aimon S, Cheng KY, Gjorgjieva J, Grunwald Kadow IC (2023).
      Global change in brain state during spontaneous and forced walk in Drosophila is composed of combined activity patterns of different neuron classes.
      eLife, accepted for publication.
    • Grunwald Kadow IC, Owald D (2022) Decision making: Dopaminergic neurons for better or worse. Current Biology. 2022 Nov 7;32(21):R1237-R1240. doi: 10.1016/j.cub.2022.09.043

    • Boehm AC, Friedrich AB, Hunt S, Bandow P, Siju KP, De Backer JF, Claussen J, Link MH, Hofmann TF, Dawid C, Grunwald Kadow IC (2022). A dopamine-gated learning circuit underpins reproductive state-dependent odor preference in Drosophila females. eLife 2022; Sep 21;11:e77643. doi: 10.7554/eLife.77643.

    • Asahina K, de Bivort BL, Grunwald Kadow IC, Yapici N. Editorial: Revisiting Behavioral Variability: What It Reveals About Neural Circuit Structure and Function. Front Behav Neurosci. 2022 Jun 15;16:956388. doi: 10.3389/fnbeh.2022.956388

    • De Backer JF and Grunwald Kadow IC (2022). A role for glia in cellular and systemic metabolism: insights from the fly. Current Opinion in Insect Science, Curr Opin Insect Sci. 2022 Oct;53:100947. doi:10.1016/j.cois.2022.100947.

    • Louis M and Grunwald Kadow IC (2022). Action selection: Neuropeptidergic gates of behavior. Current Biology 2022 Jan 10;32(1):R39-R42. doi: 10.1016/j.cub.2021.11.037
    • Üçpunar HK and Grunwald Kadow IC (2021). Flies avoid current atmospheric CO2 concentrations. Frontiers in Physiology 13 April 2021. [link]

    • Siju KP, De Backer JF, Grunwald Kadow IC (2021). Dopamine modulation of sensory processing and adaptive behavior in flies, Cell and Tissue Research, Special Issue on Olfactory Coding and Circuitries, online Jan 30. [link]

    • Kobler J, Rodriguez FJ, Petcu I, Grunwald Kadow IC (2020). Immune receptor signaling and the mushroom body mediate post-ingestion pathogen avoidance. Current Biology 30(23):4693-4709 [link]

    • Woller, A., Bandow, P., Aimon, S., Grunwald Kadow, I.C (2020). Preparing Adult Drosophila melanogaster for Whole Brain Imaging during Behavior and Stimuli Responses. J. Vis. Exp. (), e61876 [link]

    • Grunwald Kadow, IC and Gompel N (2020). Sensory Evolution: Making Sense of the Noni Scent (Dispatch). Current Biology 30, Issue 12. [link]

    • K.P. Siju, Vilim Stih, Sophie Aimon, Julijana Gjorgjieva, Ruben Portugues, Ilona C. Grunwald Kadow. Valence and state-dependent population coding in dopaminergic neurons in the fly mushroom body (2020). Current Biology 30(11):2104-2115 [link]

    • Aimon, S and Grunwald Kadow, IC. Studying complex brain dynamics using Drosophila (2020). Journal of Neurogenetics 34(1):171-177 [link]
    • Sayin S, De Backer JF, Wosniack ME, Lewis L, Siju KP, Frisch LM, Schlegel P, Edmondson-Stait A, Sharifi N, Fisher CB, Calle-Schuler S, Lauritzen S, Bock D, Costa M, Jefferis GSXE, Gjorgjieva J, Grunwald Kadow IC (2019). A neural circuit arbitrates between perseverance and withdrawal in hungry Drosophila. Neuron 104, 544–558, online Aug 27 2019. [link]
    • Kobler, JM and Grunwald Kadow IC (2019). Innate Behavior: Flies spring a surprise. eLife 2019;8:e47720 [link]

    • Quarta, C, Fisette, A, Xu, Y, Colldén, G, Legutko, B, Tseng, Y, Reim, A, Wierer, M, De Rosa, MC, Klaus, V, Rausch, R, Thaker, VV, Graf, E, Strom, TM,Poher, LM, Gruber, T, Le Thuc, O, Cebrian-Serrano, A, Kabra, D, Bellocchio, L, Woods, SC, Pflugfelder, GO, Nogueiras, R, Zeltser, L, Grunwald Kadow, IC, Moon, A, García-Cáceres, C, Mann, M, Treier, M, Doege, CA, and Tschöp MH (2019). Functional identity of hypothalamic melanocortin neurons depends on Tbx3. Nature Metabolism, 1, 222–235 [link]
    • Grunwald Kadow, IC (2018). State-dependent plasticity of innate behavior in fruit flies. Current Opinion in Neurobiology Volume 54, online [link]

    • Sardana, J, Organisti, C and Grunwald Kadow, IC (2018). Eph receptor effector Ephexin mediates olfactory dendrite targeting in Drosophila. Developmental Neurobiology 18 July 2018; DOI 10.1002/dneu.22624.[link]

    • Hinaux H, Bachem K, Battistara M, Rossi M, Xin Y, Jaenichen R, Le Poul Y, Arnoult L, Kobler JM, Grunwald Kadow IC, Rodermund L, Prud’homme B and Gompel N* (2018). Revisiting the developmental and cellular role of the pigmentation gene yellow in Drosophila using a tagged allele. Developmental Biology 2018 Jun 15;438(2):111-123. [link]

    • Hussain, A, Pooryasin, A, Zhang, M, Loschek, LF, La Fortezza, M, Friedrich, AB, Blais, CM, Üçpunar, HK, Yépez, YA, Lehmann, M, Gompel, N, Gagneur, J, Sigrist, SJ and Grunwald Kadow IC (2018). Inhibition of oxidative stress in cholinergic projection neurons fully rescues aging-associated olfactory circuit degeneration in Drosophila.
      eLife 2018;7:e32018. [link]

    • Sayın, S*, Boehm, AC*, Kobler, J*, De Backer, JF, and Grunwald Kadow, IC (2018).
      Internal state dependent odor processing and perception - the role of neuromodulation in the fly olfactory system. Front. Cell. Neurosci., 30 January 2018. * equal contribution [link]
    • Marianthi Karageorgi, Lasse B. Bräcker, Sébastien Lebreton, Caroline Minervino, Matthieu Cavey, K.P. Siju, Ilona C. Grunwald Kadow, Nicolas Gompel* and Benjamin Prud’homme* (2017).
      Evolution of multiple sensory systems drives novel egg-laying behavior in the fruit pest Drosophila suzukii.
      Current Biology 2017 Mar 20;27(6):847-853 (*co-corresponding authors)
      [download]

    • Gaspar Jékely, Sarah Melzer, Isabel Beets, Ilona C. Grunwald Kadow, Joris Koene, Sara Haddad, and Lindy Holden-Dye. The long and the short of it: A perspective on peptidergic regulation of circuits and behaviour.
      Journal of Experimental Biology  2018  221: jeb166710 doi: 10.1242/jeb.166710  Published 8 February 2018 [download]
    • Hussain A*, Zhang M*, Üçpunar HK, Svensson T, Quillery E, Gompel N, Ignell R, Grunwald Kadow IC (2016). Ionotropic chemosensory receptors mediate the taste and smell of polyamines. PLoS Biology 14:e1002454. doi:10.1371
      [download]

    • Hussain A*, Üçpunar HK*, Zhang M, Loschek LF, Grunwald Kadow IC (2016).
      Neuropeptides modulate female chemosensory processing upon mating in Drosophila.
      PLoS Biology 14:e1002455. doi: 10.1371
* equal contribution
      [download]

    2015

    • Lewis L, Siju KP, Aso Y, Friedrich AB, Bulteel AJB, Rubin GM, Grunwald Kadow IC (2015).
      A higher brain circuit for immediate integration of conflicting sensory information in Drosophila.
      Current Biology PMID: 26299514, doi: 10.1016/j.cub.2015.07.015
      [download]

    • Organisti C, Hein I, Grunwald Kadow IC*, Suzuki T* (2015).
      Flamingo, a seven-pass transmembrane cadherin, cooperates with Netrin/Frazzled in Drosophila midline pathfinding.
      Genes to Cells 20:50-67. doi: 10.1111/gtc.12202. Epub 2014 Nov 30
      [download]

    2014

    • Siju KP*, Bräcker LB*, Grunwald Kadow IC (2014).
      Neural mechanisms of context-dependent modification of CO2 avoidance behavior in fruit flies.
      Fly 8:68-74. doi: 10.4161/fly.28000 * equal contribution
      [download]

    2013

    • Hartl M, Grunwald-Kadow IC (2013).
      New roles for ‘old’ microRNAs in nervous system function and disease.
      Front Mol Neurosci doi: 10.3389/fnmol.2013.00051
      [download]

    • Bräcker LB*, Siju KP*, Varela N, Zhang M, Aso Y, Vasconcelos ML, Grunwald Kadow IC (2013).
      Essential role of the mushroom body in context-dependent CO₂avoidance in Drososphila.
      Current Biololgy 23(13):1228-34. doi: 10.1016/j.cub.2013.05.029. Epub 2013 Jun 13 * equal contribution
      [download]

    • Hein I, Suzuki T, Grunwald Kadow IC (2013).
      Gogo receptor contributes to retinotopic map formation and prevents R1- photoreceptor axon bundling.
      PLoS One 8(6):e66868. doi: 10.1371/journal.pone.0066868
      [download]

    2012

    • Stephan D, Sanchez-Soriano N, Loschek LF, Gerhards R, Gutmann S, Storchova Z, Prokop A and Grunwald Kadow IC (2012).
      Drosophila Psidin regulates olfactory neuron number and axon targeting through two distinct molecular mechanisms.
      Journal of Neuroscience 32(46):16080-94
      [download]

    • Otranto D, Cantacessi C, Lia RP, Grunwald Kadow IC, Siju KP, Dantas-Torres F, Máca J (2012).
      First laboratory Culture of Phortica variegata (Diptera, Steganinae), the Thelazia callipaeda Vector.
      Journal of Vector Ecology 37(2): 458-61
      [download]

    2011

    • Hartl M, Loschek LF, Stephan D, Siju KP, Knappmeyer C, Grunwald Kadow IC (2011).
      A New Prospero and microRNA-279 Pathway Restricts CO2 Receptor Neuron Formation.
      Journal of Neuroscience 31(44): 15660-73
      [download]

    2008

    • Cayirlioglu P*, Grunwald Kadow I*, Zhan X, Okamura K, Gunning D, Lai EC, Zipursky SL (2008).
      Hybrid Neurons in a microRNA mutant are putative evolutionary intermediates in insect CO2 sensory systems.
      Science 319: 1256-1260 * equal contribution
      [download]

    2007

    • Jones WD, Cayirlioglu P, Grunwald Kadow I, Vosshall LB (2007).
      Two chemosensory receptors together mediate carbon dioxide detection in Drosophila.
      Nature 445: 86-90
      [download]

    2001-2004

    • Grunwald IC*, Korte M*, Adelmann G, Plueck A, Kullander K, Adams RH, Frotscher M, Bonhoeffer T, Klein R (2004).
      Hippocampal plasticity requires postsynaptic ephrinBs.
      Nature Neuroscience 7: 33-40 * equal contribution
      [download]

    • Zorner B, Wolfer DP, Brandis D, Kretz O, Zacher C, Madani R, Grunwald I, Lipp HP, Klein R, Henn FA, Gass P (2003).
      Forebrain-specific trkB-receptor knockout mice: behaviorally more hyperactive than "depressive".
      Biol Psychiatry 54: 972-982 
      [download]

    • Grunwald IC, Klein R (2002).
      Axon guidance: receptor complexes and signaling mechanisms.
      Current Opinion Neurobiology 12: 250-259
      [download]

    • Grunwald IC*, Korte M*, Wolfer D, Wilkinson GA, Unsicker K, Lipp HP, Bonhoeffer T, Klein R (2001)
      Kinase-independent requirement of EphB2 receptors in hippocampal synaptic plasticity.
      Neuron 32: 1027-1040 * equal contribution
      [download]

    Reviews

    • Siju KP, De Backer JF, Grunwald Kadow IC. Dopamine modulation of sensory processing and adaptive behavior in flies, Cell and Tissue Research, Special Issue on Olfactory Coding and Circuitries, in press.

    • Grunwald Kadow, IC (2018). State-dependent plasticity of innate behavior in fruit flies. Current Opinion in Neurobiology Volume 54, online [link]

    • Sayın, S*, Boehm, AC*, Kobler, J*, De Backer, JF, and Grunwald Kadow, IC (2018).
      Internal state dependent odor processing and perception - the role of neuromodulation in the fly olfactory system.
      Frontiers of Cellular Neuroscience, in press. * equal contribution [link]

    • Gaspar Jekely, Sarah Melzer, Isabel Beets, Ilona C. Grunwald Kadow, Joris Koene, Sara Haddad, and Lindy Holden-Dye.
      The long and the short of it: A perspective on peptidergic regulation of circuits and behaviour.
      Journal of Experimental Biology  2018  221: jeb166710 doi: 10.1242/jeb.166710  Published 8 February 2018 [download]

    • Siju KP, Bräcker LB, Grunwald Kadow IC (2014).
      Neural mechanisms of context-dependent modification of CO2 avoidance behavior in fruit flies.
      Fly 8:68-74. doi: 10.4161/fly.28000 [download]

    • Hartl M, Grunwald-Kadow IC (2013).
      New roles for ‘old’ microRNAs in nervous system function and disease.
      Frontiers in Molecular Neuroscience doi: 10.3389/fnmol.2013.00051
      [download]

    • Grunwald IC, Klein R (2002).
      Axon guidance: receptor complexes and signaling mechanisms.
      Current Opinion Neurobiology 12: 250-259
      [download]